产品货号：
Z37118
中文名称：
KU70/XRCC6抗体
英文名称：
Anti-KU70/XRCC6 Antibody (Clone#9B6)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KU70/XRCC6 Antibody (Clone#9B6) |
| 指标别名 | 5 dRP lyase Ku70;70kDa subunit of Ku antigen;CTC75;CTCBF;DNA repair protein XRCC6;G22P1;KU70;ML8;Thyroid lupus autoantigen;TLAA;XRCC6 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | XRCC6 |
| 克隆号 | 9B6 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | A synthetic peptide corresponding to a sequence at C-terminus of human Ku70 (464-496aa AIVEKLRFTYRSDSFENPVLQQHFRNLEALALD),different from the related mouse sequence by one amino acid. |
| 实际分子量 | 70KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | XRCC6 (X-Ray Repair,Complementing Defective,In Chinese Hamster,6),also called Ku70,G22P1 or TLAA,is a protein that in humans,is encoded by the XRCC6 gene.In addition,the XRCC6 gene encodes subunit p70 of the p70/p80 autoantigen which consists of 2 proteins of molecular mass of approximately 70,000 and 80,000 daltons that dimerize to form a 10 S DNA-binding complex.The XRCC6 gene is mapped to 22q13.2.XRCC6 and Mre11 are differentially expressed during meiosis.XRCC6 interacts with Baxa,a mediator of mitochondrial-dependent apoptosis.Disruption of both FANCC and XRCC6 suppressed sensitivity to crosslinking agents,diminished chromosome breaks,and reversed defective homologous recombination.Ku70 binds directly to free DNA ends,committing them to NHEJ repair.In early meiotic prophase,however,when meiotic recombination is most probably initiated,Mre11 was abundant,whereas XRCC6 was not detectable. |
| Uniprot ID | P12956 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | X-ray repair complementing defective repair in Chinese hamster cells 6 |
| 蛋白名全称 | X-ray repair cross-complementing protein 6 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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